NEUROMOTIV - Neurofarmalogía de la Conducta Motivada
Coordinació:
María de las Mercedes Correa Sanz
Dep. de Psicologia Bàsica, Clínica i Psicobiologia
Nombre de doctors: 2
El nostre equip estudia principalment els mecanismes cerebrals que regulen aspectes de la motivació relacionats amb l’activació conductual i la presa de decisions basada en l’esforç. Treballem amb models animals de símptomes que també es manifesten humans. Objectiu: el nostre treball se centra en dues àrees: 1) estudiar les interaccions neuroquímiques i els circuits anatòmics que regulen l’activació conductual i els aspectes de la motivació relacionats amb l’esforç i l’activitat física, i 2) desenvolupar procediments que puguen usar-se com a models animals per a estudiar els símptomes psicopatològics i desenvolupar nous tractaments farmacològics i estratègies terapèutiques conductuals.
Direcció |
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María de las Mercedes Correa Sanz |
Personal investigador | Dedicació al grup |
---|---|
Carratalá Ros, Carla | 100 % |
Personal investigador en Formació | Dedicació al grup |
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Arias de Saavedra Sandoval, Edgar Andoni | 100 % |
Martínez Verdú, Andrea | 100 % |
Matas Navarro, Paula | 100 % |
Olivares García, Régulo Luis | 100 % |
- Implicació del circuit dopaminèrgic mesolímbic i mesocortical en la motivació per reforçadors naturals i a drogues d'abús
- Neurobiologia de l’exercici físic
- Neurofarmacologia i genètica de la malaltia de Parkinson en models animals
Organisme | Codi | Títol | Inici | Fi |
---|---|---|---|---|
GV | PROMETEO/2020/032 | DIFERENCIAS INDIVIDUALES Y ENTRE SEXOS EN LA ELECCIÓN DE ACTIVIDADES QUE REQUIEREN ESFUERZO Y UN ESTILO DE VIDA ACTIVO: ESTUDIO DE LOS SISTEMAS DOPAMINÉRGICOS Y DE LA NEUROPROTECCIÓN MEDIANTE EJERCICIO FÍSICO | 01/01/2021 | 31/12/2021 |
GV | PROMETEO/2020/032 | DIFERENCIAS INDIVIDUALES Y ENTRE SEXOS EN LA ELECCIÓN DE ACTIVIDADES QUE REQUIEREN ESFUERZO Y UN ESTILO DE VIDA ACTIVO: ESTUDIO DE LOS SISTEMAS DOPAMINÉRGICOS Y DE LA NEUROPROTECCIÓN MEDIANTE EJERCICIO FÍSICO | 01/01/2020 | 31/03/2021 |
MCIU | RTI2018-101424-B-I00 | FACTORS INFLUENCING LIFELONG EXERCISE IN BOTH SEXES: EARLY EXPERIENCE, DOPAMINERGIC PLASTICITY AND INDIVIDUAL DIFFERENCES (EXERDANERGIA) | 01/01/2019 | 31/12/2021 |
UJI | UJI-B2018-31 | IMPACTO DEL ESTRÉS PRODUCIDO POR LA SEPARACIÓN MATERNA SOBRE EL SISTEMA DOPAMINÉRGICO Y LAS CONDUCTAS MOTIVADAS QUE REQUIEREN ESFUERZO EN LA EDAD ADULTA: ESTUDIO EN RATONES DE AMBOS SEXOS | 01/01/2019 | 31/12/2021 |
GV | AICO/2018/044 | DIFERENCIAS ENTRE SEXOS EN LAS BASES NEURALES Y EL TRATAMIENTO DE LA ANERGIA Y LA FATIGA EN LA DEPRESIÓN: ESTUDIO DEL SISTEMA DOPAMINÉRGICO | 01/01/2018 | 31/12/2019 |
Articles en revistes
- Impact of Caffeine on Ethanol-Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens - Article
- Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine - Article
- The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology - Article
- Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice - Article
- Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction - Article
- Lisdexamfetamine suppresses instrumental and consummatory behaviors supported by foods with varying degrees of palatability: Exploration of a binge-like eating model - Article
- The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making - Article
- Effort-related decision making in humanized COMT mice: Effects of Val(158)Met polymorphisms and possible implications for negative symptoms in humans - Article
- Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia - Article
- The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures - Article
- Behavioral and dopamine transporter binding properties of the modafinil analog (S,S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding - Article
- Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonism - Article
- The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding - Article
- Caffeine modulates voluntary alcohol intake in mice depending on the access conditions: Involvement of adenosine receptors and the role of individual differences - Article
- Patterns of Neural Responses, Pavlovian-to-Instrumental Transfer, and Prediction of Relapse - Material editorial
- Individual differences in the energizing effects of caffeine on effort-based decision-making tests in rats - Article
- Dopamine depletion shifts behavior from activity based reinforcers to more sedentary ones and adenosine receptor antagonism reverses that shift: Relation to ventral striatum DARPP32 phosphorylation patterns - Article
- The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation - Revisió
- The monoamine-oxidase B inhibitor deprenyl increases selection of higheffort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions - Article
- Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion - Article
- Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression - Revisió
- Neurobiology and pharmacology of activational and effort-related aspects of motivation: rodent studies - Revisió
- Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research - Revisió
- Partial reversal of the effort-related motivational effects of tetrabenazine with the MAO-B inhibitor deprenyl (selegiline): Implications for treating motivational dysfunctions - Article
- Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala - Article
- Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression - Article
- Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions - Article
- Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat - Article
- Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040 - Article
- The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences - Article
- Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice - Article
- Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology - Article
- Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) Receptors - Article
- The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine - Article
- Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior - Article
- Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization - Article
- Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology - Revisió
- Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism - Article
- Parsing the Role of Mesolimbic Dopamine in Specific Aspects of Motivation: Behavioral Activation, Invigoration, and Effort-Based Decision Making
- Neurobiology of Effort and the Role of Mesolimbic Dopamine
- Motor function and motivation
- Mesolimbic Dopamine and the Regulation of Motivated Behavior
- Anergia and Effort-Related Aspects of Motivational Dysfunction in Animal Models of Depressive Symptoms: The Role of Mesolimbic Dopamine and Related Circuitry
Tesis dirigides
- Involvement of dopamine in the regulation of dysfunctions related to depression in rodent models: motivational versus emotional symptoms
Autoria: Carratalá Ros, Carla. Institució: Universitat Jaume I. Data lectura: 25/03/20Direcció: Correa Sanz, María de las Mercedes; Salamone, John
- Behavioral and neurochemical assessment of the role of ERK pathway in the psychopharmacological effects of ethanol, caffeine and of their interaction
Autoria: Porru, Simona. Institució: Universitat Jaume I. Data lectura: 04/02/20Direcció: Correa Sanz, María de las Mercedes
- Involvement of adenosinergic and dopaminergic systems in the regulation of alcohol or sucrose intake: studies in rodent models of self-administration
Autoria: San Miguel Segura, Noemí. Institució: Universitat Jaume I. Data lectura: 18/07/17Direcció: Correa Sanz, María de las Mercedes
- The effects of adenosine antagonists on distinct aspects of motivated behavior: interaction with ethanol and dopamine depletion
Autoria: López Cruz, Laura. Institució: Universitat Jaume I. Data lectura: 18/05/16Direcció: Correa Sanz, María de las Mercedes; Salamone, John
- Screenings farmacèutics per psicofàrmacs
- Col·laboració amb el Laboratori de Neurociència Conductual del Departament de Psicologia de la Universitat de Connecticut, Estats Units.
- Dopamina
- Accumbens
- Motivació
- Esforç
- Exercici
- Depressió
- Anergia
- Addicció
- Rosegadors