Universitat Jaume I

UJI
Serveis
OCIT
Universitat Jaume I

NEUROMOTIV - Neurofarmalogía de la Conducta Motivada

Coordinació:
María de las Mercedes Correa Sanz

Dep. de Psicologia Bàsica, Clínica i Psicobiologia

Nombre de doctors: 2

Àrees d'aplicació:

El nostre equip estudia principalment els mecanismes cerebrals que regulen aspectes de la motivació relacionats amb l’activació conductual i la presa de decisions basada en l’esforç. Treballem amb models animals de símptomes que també es manifesten humans. Objectiu: el nostre treball se centra en dues àrees: 1) estudiar les interaccions neuroquímiques i els circuits anatòmics que regulen l’activació conductual i els aspectes de la motivació relacionats amb l’esforç i l’activitat física, i 2) desenvolupar procediments que puguen usar-se com a models animals per a estudiar els símptomes psicopatològics i desenvolupar nous tractaments farmacològics i estratègies terapèutiques conductuals.

Membres

Línies d'investigació

Membres

Direcció

María de las Mercedes Correa Sanz

Personal investigador	Dedicació al grup
Carratalá Ros, Carla	100 %

Personal investigador en Formació	Dedicació al grup
Arias de Saavedra Sandoval, Edgar Andoni	100 %
Martínez Verdú, Andrea	100 %
Matas Navarro, Paula	100 %
Olivares García, Régulo Luis	100 %

Projectes

Organisme	Codi	Títol	Inici	Fi
GV	PROMETEO/2020/032	DIFERENCIAS INDIVIDUALES Y ENTRE SEXOS EN LA ELECCIÓN DE ACTIVIDADES QUE REQUIEREN ESFUERZO Y UN ESTILO DE VIDA ACTIVO: ESTUDIO DE LOS SISTEMAS DOPAMINÉRGICOS Y DE LA NEUROPROTECCIÓN MEDIANTE EJERCICIO FÍSICO	01/01/2021	31/12/2021
GV	PROMETEO/2020/032	DIFERENCIAS INDIVIDUALES Y ENTRE SEXOS EN LA ELECCIÓN DE ACTIVIDADES QUE REQUIEREN ESFUERZO Y UN ESTILO DE VIDA ACTIVO: ESTUDIO DE LOS SISTEMAS DOPAMINÉRGICOS Y DE LA NEUROPROTECCIÓN MEDIANTE EJERCICIO FÍSICO	01/01/2020	31/03/2021
MCIU	RTI2018-101424-B-I00	FACTORS INFLUENCING LIFELONG EXERCISE IN BOTH SEXES: EARLY EXPERIENCE, DOPAMINERGIC PLASTICITY AND INDIVIDUAL DIFFERENCES (EXERDANERGIA)	01/01/2019	31/12/2021
UJI	UJI-B2018-31	IMPACTO DEL ESTRÉS PRODUCIDO POR LA SEPARACIÓN MATERNA SOBRE EL SISTEMA DOPAMINÉRGICO Y LAS CONDUCTAS MOTIVADAS QUE REQUIEREN ESFUERZO EN LA EDAD ADULTA: ESTUDIO EN RATONES DE AMBOS SEXOS	01/01/2019	31/12/2021
GV	AICO/2018/044	DIFERENCIAS ENTRE SEXOS EN LAS BASES NEURALES Y EL TRATAMIENTO DE LA ANERGIA Y LA FATIGA EN LA DEPRESIÓN: ESTUDIO DEL SISTEMA DOPAMINÉRGICO	01/01/2018	31/12/2019

Publicacions i tesis

Articles en revistes

Impact of Caffeine on Ethanol-Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens - Article

Simona Porru, Laura López Cruz, Carla Carratalá Ros, John D Salamone, Elio Acquas, María de las Mercedes Correa Sanz.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH; 3 pp. 608-619. (2021). ISSN: 0145-6008

Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine - Article

Rose E. Presby, Renee A. Rotolo, Erin M. Hurley, Sarah M. Ferrigno, Cayla E. Murphy, Haley P. McMullen, Pranally A. Desai, Emma M. Zorda, Felicita B. Kuperwasser, Carla Carratalá Ros, María de las Mercedes Correa Sanz, John D. Salamone.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 202 pp. --. (2021). ISSN: 0091-3057

The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology - Article

R.A. Rotolo, R.E. Presby, O. Tracy, S. Asar, J.H. Yang, María de las Mercedes Correa Sanz, F. Murray, J.D Salamone.

NEUROPHARMACOLOGY; 183 pp. --. (2021). ISSN: 0028-3908

Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice - Article

Simona Porru, Riccardo Maccioni, Valentina Bassareo, Alessandra T. Peana, John D. Salamone, María de las Mercedes Correa Sanz, Elio Acquas.

JOURNAL OF PSYCHOPHARMACOLOGY ; 12 pp. 1357-1370. (2020). ISSN: 0269-8811

Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction - Article

Jen-Hau Yang, Rose E Presby, Adam A. Jarvie, Renee A. Rotolo, R. Holly Fitch, María de las Mercedes Correa Sanz, John D. Salamone.

PSYCHOPHARMACOLOGY ; 1 pp. 33-43. (2020). ISSN: 0033-3158

Lisdexamfetamine suppresses instrumental and consummatory behaviors supported by foods with varying degrees of palatability: Exploration of a binge-like eating model - Article

R.E Presby, , R.A Rotolo, J.-H Yang, María de las Mercedes Correa Sanz, J.D Salamone.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 189 pp. --. (2020). ISSN: 0091-3057

The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making - Article

Marta Pardo, Nicholas E. Paul, Lyndsey E. Collins-Praino, John D. Salamone, María de las Mercedes Correa Sanz.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 198 pp. --. (2020). ISSN: 0091-3057

Effort-related decision making in humanized COMT mice: Effects of Val(158)Met polymorphisms and possible implications for negative symptoms in humans - Article

Jen-Hau Yang, Rose E. Presby, Suzanne Cayer, Renee A. Rotolo, Peter A. Perrino, R. Holly Fitch, María de las Mercedes Correa Sanz, Elissa J. Chesler, John D. Salamone.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 196 pp. --. (2020). ISSN: 0091-3057

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia - Article

Carla Carratalá Ros, Laura López Cruz, Noemí San Miguel Segura, Patricia Ibáñez Marín, Andrea Martínez Verdú, J.D Salamone, María de las Mercedes Correa Sanz.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE; 13 pp. --. (2020). ISSN: 1662-5153

The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures - Article

Jen-Hau Yang, Rose E. Presby, Renee A. Rotolo, Taina Quiles, Kevin Okifo, Emma Zorda, Roslyn Holly Fitch, María de las Mercedes Correa Sanz, John D. Salamone.

PSYCHOPHARMACOLOGY ; 9 pp. 2845-2854. (2020). ISSN: 0033-3158

Behavioral and dopamine transporter binding properties of the modafinil analog (S,S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding - Article

Renee A. Rotolo, Predrag Kalaba, Vladimir Dragacevic, Rose E Presby, Julia Neri, Emily Robertson, Jen-Hau Yang, María de las Mercedes Correa Sanz, Vasiliy Bakulev, Natalia N. Volkova, Christian Pifl, Gert Lubec, John D. Salamone .

PSYCHOPHARMACOLOGY ; 237 pp. 3459-3470. (2020). ISSN: 0033-3158

Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonism - Article

María de las Mercedes Correa Sanz, Marta Pardo, Carla Carratalá Ros, Andrea Martínez Verdú, John D. Salamone.

BEHAVIOURAL PHARMACOLOGY ; 6 pp. 553-564. (2020). ISSN: 0955-8810

The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding - Article

Renee A. Rotolo, Vladimir Dragacevic, Predrag Kalaba, Ernst Urban, Martin Zehl, Alexander Roller, Judith Wackerlig, Thierry Langer, Marco Pistis, Maria Antonietta De Luca, Francesca Caria, Rebecca Schwartz, Rose E. Presby, Jen-Hau Yang, Shanna Samels, María de las Mercedes Correa Sanz, Gert Lubec, John D. Salamone.

FRONTIERS IN PHARMACOLOGY; 10 pp. --. (2019). ISSN: 1663-9812

Caffeine modulates voluntary alcohol intake in mice depending on the access conditions: Involvement of adenosine receptors and the role of individual differences - Article

Noemí San Miguel Segura, Laura López Cruz, C.E. Müller, J.D. Salamone, María de las Mercedes Correa Sanz.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 186 pp. --. (2019). ISSN: 0091-3057

Patterns of Neural Responses, Pavlovian-to-Instrumental Transfer, and Prediction of Relapse - Material editorial

J.D. Salamone, María de las Mercedes Correa Sanz.

BIOLOGICAL PSYCHIATRY; 11 pp. 807-808. (2019). ISSN: 0006-3223

Individual differences in the energizing effects of caffeine on effort-based decision-making tests in rats - Article

Noemí San Miguel Segura, Marta Pardo, Carla Carratalá Ros, Laura López Cruz, John D. Salamone, María de las Mercedes Correa Sanz.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 169 pp. 27-34. (2018). ISSN: 0091-3057

Dopamine depletion shifts behavior from activity based reinforcers to more sedentary ones and adenosine receptor antagonism reverses that shift: Relation to ventral striatum DARPP32 phosphorylation patterns - Article

Laura López Cruz, Noemí San Miguel Segura, Carla Carratalá Ros, Lidon Monferrer Sales, John D Salamone, María de las Mercedes Correa Sanz.

NEUROPHARMACOLOGY; 138 pp. 349-359. (2018). ISSN: 0028-3908

The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation - Revisió

John D. Salamone, María de las Mercedes Correa Sanz, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo, Rose E. Presby.

PHARMACOLOGICAL REVIEWS ; 4 pp. 747-762. (2018). ISSN: 0031-6997

The monoamine-oxidase B inhibitor deprenyl increases selection of higheffort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions - Article

Samantha E. Yohn, Shanika Reynolds, Giuseppe Tripodi, María de las Mercedes Correa Sanz, John D. Salamone.

BEHAVIOURAL BRAIN RESEARCH ; 342 pp. 27-34. (2018). ISSN: 0166-4328

Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion - Article

María de las Mercedes Correa Sanz, Noemí San Miguel Segura, Laura López Cruz, Carla Carratalá Ros, Régulo Luis Olivares García, John D. Salamone.

FRONTIERS IN PSYCHIATRY; 9 pp. --. (2018). ISSN: 1664-0640

Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression - Revisió

Laura López Cruz, J.D Salamone, María de las Mercedes Correa Sanz.

FRONTIERS IN PHARMACOLOGY; 9 pp. --. (2018). ISSN: 1663-9812

Neurobiology and pharmacology of activational and effort-related aspects of motivation: rodent studies - Revisió

J.D. Salamone, María de las Mercedes Correa Sanz.

CURRENT OPINION IN BEHAVIORAL SCIENCES; 22 pp. 114-120. (2018). ISSN: 2352-1546

Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research - Revisió

John D. Salamone, María de las Mercedes Correa Sanz, Jen-Hau Yang, Renee Rotolo, Rose Presby.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE; 12 pp. 1-13. (2018). ISSN: 1662-5153

Partial reversal of the effort-related motivational effects of tetrabenazine with the MAO-B inhibitor deprenyl (selegiline): Implications for treating motivational dysfunctions - Article

Hector Contreras-Mora , Margaret A. Rowland, Samantha E. Yohn, María de las Mercedes Correa Sanz, John D. Salamone.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 166 pp. 13-20. (2018). ISSN: 0091-3057

Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala - Article

Laura López Cruz, María Carbó Gas, Marta Pardo Andrés, Pilar Bayarri Iturralde, Olga Valverde, Catherine Ledent, John D. Salamone, María de las Mercedes Correa Sanz.

BEHAVIOURAL BRAIN RESEARCH ; 321 pp. 8-17. (2017). ISSN: 0166-4328

Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression - Article

Samantha E Yohn, Dea Gorka, Anisha Mistry, Samantha Collins, Emily Qian, María de las Mercedes Correa Sanz, Arushi Manchanda, Robin H Bogner, John Salamone.

JOURNAL OF NATURAL PRODUCTS ; 10 pp. 2839-2844. (2017). ISSN: 0163-3864

Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions - Article

Samantha E. Yohn, Daniela Alberati, María de las Mercedes Correa Sanz, John D. Salamone.

PSYCHOPHARMACOLOGY ; 9-10 pp. 1525-1534. (2017). ISSN: 0033-3158

Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat - Article

Samantha E. Yohn, Laura López Cruz, Peter H. Hutson, María de las Mercedes Correa Sanz, John D. Salamone.

PSYCHOPHARMACOLOGY ; 6 pp. 949-960. (2016). ISSN: 0033-3158

Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040 - Article

S.E. Yohn, A. Gogoj, A. Haque, Laura López Cruz, P. Huxley, P. Basquín, María de las Mercedes Correa Sanz, JD. Salamone.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 148 pp. 84-91. (2016). ISSN: 0091-3057

The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences - Article

JD. Salamone, María de las Mercedes Correa Sanz, S. Yohn, Laura López Cruz, Noemí San Miguel Segura, L. Alatorre.

BEHAVIOURAL PROCESSES ; 127 pp. 3-17. (2016). ISSN: 0376-6357

Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice - Article

María de las Mercedes Correa Sanz, Marta Pardo Andrés, Pilar Bayarri Iturralde, Laura López Cruz, Noemí San Miguel Segura, O Valverde, C Ledent, J.D. Salamone.

PSYCHOPHARMACOLOGY ; 3 pp. 393-404. (2016). ISSN: 0033-3158

Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology - Article

SE. Yohn, EE. Errante, A. Rosenbloom-Snow, M. Somerville, M. Rowland, K. Tokarski, N. Zafar, María de las Mercedes Correa Sanz, JD. Salamone.

NEUROPHARMACOLOGY; 109 pp. 270-280. (2016). ISSN: 0028-3908

Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) Receptors - Article

Laura López Cruz, Noemí San Miguel Segura, Pilar Bayarri Iturralde, Y. Baqi, C.E. Mueller, J.D. Salamone, María de las Mercedes Correa Sanz.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE; 10 pp. 1-15. (2016). ISSN: 1662-5153

The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine - Article

Podurgiel SJ , Yohn SE , Dortche K , María de las Mercedes Correa Sanz, Salamone JD .

BEHAVIOURAL BRAIN RESEARCH ; 298 pp. --. (2016). ISSN: 0166-4328

Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior - Article

SE. Yohn, SL. Collins, HM. Contreras-Mora, EL Errante, MA. Rowland, María de las Mercedes Correa Sanz, HD. Salamone.

NEUROPSYCHOPHARMACOLOGY; 3 pp. 686-694. (2016). ISSN: 0893-133X

Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization - Article

SE Yohn, Y Arif, A Haley, G Tripodi, Y Baqi, CE Muller, Noemí San Miguel Segura, María de las Mercedes Correa Sanz, JD Salamone.

PSYCHOPHARMACOLOGY ; 19-20 pp. 3575-3586. (2016). ISSN: 0033-3158

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology - Revisió

J D. Salamone, SE. Yohn, Laura López Cruz, Noemí San Miguel Segura, María de las Mercedes Correa Sanz.

BRAIN ; 139 pp. 1325-1347. (2016). ISSN: 0006-8950

Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism - Article

Podurgiel SJ , Spencer T , Kovner R , Baqi Y , Müller CE , María de las Mercedes Correa Sanz, Salamone JD .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 140 pp. 62-67. (2016). ISSN: 0091-3057

Capítols de llibres

Parsing the Role of Mesolimbic Dopamine in Specific Aspects of Motivation: Behavioral Activation, Invigoration, and Effort-Based Decision Making

John D. Salamone, María de las Mercedes Correa Sanz.

Advances in Motivation Science. Academic Press, Londres (Reino Unido). (2018). ISBN: 9780128141717

Neurobiology of Effort and the Role of Mesolimbic Dopamine

John D. Salamone, María de las Mercedes Correa Sanz.

Recent Developments in Neuroscience Research on Human Motivation. Emerald, Bingley (Reino Unido). (2017). ISBN: 9781786354747

Motor function and motivation

John D. Salamone, María de las Mercedes Correa Sanz.

Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, Amsterdam (Paises Bajos). (2017). ISBN: 9780128093245

Mesolimbic Dopamine and the Regulation of Motivated Behavior

J.D Salamone, Marta Pardo Andrés, S.E Yohn, Laura López Cruz, Noemí San Miguel Segura, María de las Mercedes Correa Sanz.

Behavioral Neuroscience of Motivation. Springer, (756) (Suiza). (2016). ISBN: 9783319269337

Treballs presentats en congressos publicats

Anergia and Effort-Related Aspects of Motivational Dysfunction in Animal Models of Depressive Symptoms: The Role of Mesolimbic Dopamine and Related Circuitry

John Salamone, María de las Mercedes Correa Sanz, Samantha Yohn, Renee Rotolo, Jeu-Hau Yan, Rose Presby.

73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP). New York (Estados Unidos de América)

2018. ISSN: 0006-3223

Tesis dirigides

Involvement of dopamine in the regulation of dysfunctions related to depression in rodent models: motivational versus emotional symptoms
Autoria: Carratalá Ros, Carla. Institució: Universitat Jaume I. Data lectura: 25/03/20

Direcció: Correa Sanz, María de las Mercedes; Salamone, John
Behavioral and neurochemical assessment of the role of ERK pathway in the psychopharmacological effects of ethanol, caffeine and of their interaction
Autoria: Porru, Simona. Institució: Universitat Jaume I. Data lectura: 04/02/20

Direcció: Correa Sanz, María de las Mercedes
Involvement of adenosinergic and dopaminergic systems in the regulation of alcohol or sucrose intake: studies in rodent models of self-administration
Autoria: San Miguel Segura, Noemí. Institució: Universitat Jaume I. Data lectura: 18/07/17

Direcció: Correa Sanz, María de las Mercedes
The effects of adenosine antagonists on distinct aspects of motivated behavior: interaction with ethanol and dopamine depletion
Autoria: López Cruz, Laura. Institució: Universitat Jaume I. Data lectura: 18/05/16

Direcció: Correa Sanz, María de las Mercedes; Salamone, John