Neurofarmalogia de la Conducta Motivada
NEUROMOTIV
Dopamina, Accumbens, Motivació, Esforç, Exercici, Depressió, Anergia, Addicció, Rosegadors| Coordinació |
| Correa Sanz, María de las Mercedes |
| Centre |
| FACULTAT DE CIÈNCIES DE LA SALUT |
| Departament |
| Dep. de Psicologia Bàsica, Clínica i Psicobiologia |
| Personal investigador en Formació | Dedicació al grup |
| Arias de Saavedra Sandoval, Edgar Andoni | 100 % |
| Carratalá Ros, Carla | 100 % |
| Martínez Verdú, Andrea | 100 % |
| Porru, Simona | 100 % |
Línies d'investigació
- Implicació del circuit dopaminèrgic mesolímbic i mesocortical en la motivació per reforçadors naturals i a drogues d'abús
- Neurobiologia de l’exercici físic
- Neurofarmacologia i genètica de la malaltia de Parkinson en models animals
Serveis tecnològics i tècniques disponibles
- Screenings farmacèutics per psicofàrmacs
Codis UNESCO
(Veure detalls)- 61.13.01 - ALCOHOLISMO (ver 3309.01)
- 61.13.02 - REACCIONES DEL COMPORTAMIENTO
- 61.13.03 - ABUSO DE DROGAS
- 61.13.04 - EFECTO DE LAS DROGAS (ver 3208.02 y 08)
Projectes d'investigació finançats amb fons públics
(Veure detalls)| Organisme | Codi | Títol | Inici | Fi |
| MCIU | RTI2018-101424-B-I00 | FACTORS INFLUENCING LIFELONG EXERCISE IN BOTH SEXES: EARLY EXPERIENCE, DOPAMINERGIC PLASTICITY AND INDIVIDUAL DIFFERENCES (EXERDANERGIA) | 01/01/2019 | 31/12/2021 |
| UJI | UJI-B2018-31 | IMPACTO DEL ESTRÉS PRODUCIDO POR LA SEPARACIÓN MATERNA SOBRE EL SISTEMA DOPAMINÉRGICO Y LAS CONDUCTAS MOTIVADAS QUE REQUIEREN ESFUERZO EN LA EDAD ADULTA: ESTUDIO EN RATONES DE AMBOS SEXOS | 01/01/2019 | 31/12/2021 |
| GV | AICO/2018/044 | DIFERENCIAS ENTRE SEXOS EN LAS BASES NEURALES Y EL TRATAMIENTO DE LA ANERGIA Y LA FATIGA EN LA DEPRESIÓN: ESTUDIO DEL SISTEMA DOPAMINÉRGICO | 01/01/2018 | 31/12/2019 |
| MINECO | PSI2015-68497-R | CORRELATOS CONDUCTUALES Y NEUROBIOLÓGICOS DE LA VULNERABILIDAD Y LA RELISENCIA A LA ANERGIA EN RATAS: APROXIMACIÓN FARMACOTERAPÉUTICA BASADA EN LAS DIFERENCIAS INDIVIDUALES | 01/01/2016 | 30/04/2019 |
Publicacions científiques dels membres del grup
Articles en revistes
(Veure detalls)
- The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding - Article
Renee A. Rotolo, Vladimir Dragacevic, Predrag Kalaba, Ernst Urban, Martin Zehl, Alexander Roller, Judith Wackerlig, Thierry Langer, Marco Pistis, Maria Antonietta De Luca, Francesca Caria, Rebecca Schwartz, Rose E. Presby, Jen-Hau Yang, Shanna Samels, María de las Mercedes Correa Sanz, Gert Lubec, John D. Salamone.
FRONTIERS IN PHARMACOLOGY; 10 pp. --. (2019). ISSN: 1663-9812
- Caffeine modulates voluntary alcohol intake in mice depending on the access conditions: Involvement of adenosine receptors and the role of individual differences - Article
Noemí San Miguel Segura, Laura López Cruz, C.E. Müller, J.D. Salamone, María de las Mercedes Correa Sanz.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 186 pp. --. (2019). ISSN: 0091-3057
- Patterns of Neural Responses, Pavlovian-to-Instrumental Transfer, and Prediction of Relapse - Material editorial
J.D. Salamone, María de las Mercedes Correa Sanz.
BIOLOGICAL PSYCHIATRY; 11 pp. 807-808. (2019). ISSN: 0006-3223
- Neurobiology and pharmacology of activational and effort-related aspects of motivation: rodent studies - Revisió
J.D. Salamone, María de las Mercedes Correa Sanz.
CURRENT OPINION IN BEHAVIORAL SCIENCES; 22 pp. 114-120. (2018). ISSN: 2352-1546
- The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation - Revisió
John D. Salamone, María de las Mercedes Correa Sanz, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo, Rose E. Presby.
PHARMACOLOGICAL REVIEWS ; 4 pp. 747-762. (2018). ISSN: 0031-6997
- Dopamine depletion shifts behavior from activity based reinforcers to more sedentary ones and adenosine receptor antagonism reverses that shift: Relation to ventral striatum DARPP32 phosphorylation patterns - Article
Laura López Cruz, Noemí San Miguel Segura, Carla Carratalá Ros, Lidon Monferrer Sales, John D Salamone, María de las Mercedes Correa Sanz.
NEUROPHARMACOLOGY; 138 pp. 349-359. (2018). ISSN: 0028-3908
- The monoamine-oxidase B inhibitor deprenyl increases selection of higheffort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions - Article
Samantha E. Yohn, Shanika Reynolds, Giuseppe Tripodi, María de las Mercedes Correa Sanz, John D. Salamone.
BEHAVIOURAL BRAIN RESEARCH ; 342 pp. 27-34. (2018). ISSN: 0166-4328
- Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression - Revisió
Laura López Cruz, J.D Salamone, María de las Mercedes Correa Sanz.
FRONTIERS IN PHARMACOLOGY; 9 pp. --. (2018). ISSN: 1663-9812
- Partial reversal of the effort-related motivational effects of tetrabenazine with the MAO-B inhibitor deprenyl (selegiline): Implications for treating motivational dysfunctions - Article
Hector Contreras-Mora , Margaret A. Rowland, Samantha E. Yohn, María de las Mercedes Correa Sanz, John D. Salamone.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 166 pp. 13-20. (2018). ISSN: 0091-3057
- Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research - Revisió
John D. Salamone, María de las Mercedes Correa Sanz, Jen-Hau Yang, Renee Rotolo, Rose Presby.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE; 12 pp. 1-13. (2018). ISSN: 1662-5153
- Individual differences in the energizing effects of caffeine on effort-based decision-making tests in rats - Article
Noemí San Miguel Segura, Marta Pardo, Carla Carratalá Ros, Laura López Cruz, John D. Salamone, María de las Mercedes Correa Sanz.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 169 pp. 27-34. (2018). ISSN: 0091-3057
- Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion - Article
María de las Mercedes Correa Sanz, Noemí San Miguel Segura, Laura López Cruz, Carla Carratalá Ros, Régulo Luis Olivares García, John D. Salamone.
FRONTIERS IN PSYCHIATRY; 9 pp. --. (2018). ISSN: 1664-0640
- Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala - Article
Laura López Cruz, María Carbó Gas, Marta Pardo Andrés, Pilar Bayarri Iturralde, Olga Valverde, Catherine Ledent, John D. Salamone, María de las Mercedes Correa Sanz.
BEHAVIOURAL BRAIN RESEARCH ; 321 pp. 8-17. (2017). ISSN: 0166-4328
- Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions - Article
Samantha E. Yohn, Daniela Alberati, María de las Mercedes Correa Sanz, John D. Salamone.
PSYCHOPHARMACOLOGY ; 9-10 pp. 1525-1534. (2017). ISSN: 0033-3158
- Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression - Article
Samantha E Yohn, Dea Gorka, Anisha Mistry, Samantha Collins, Emily Qian, María de las Mercedes Correa Sanz, Arushi Manchanda, Robin H Bogner, John Salamone.
JOURNAL OF NATURAL PRODUCTS ; 10 pp. 2839-2844. (2017). ISSN: 0163-3864
- Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) Receptors - Article
Laura López Cruz, Noemí San Miguel Segura, Pilar Bayarri Iturralde, Y. Baqi, C.E. Mueller, J.D. Salamone, María de las Mercedes Correa Sanz.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE; 10 pp. 1-15. (2016). ISSN: 1662-5153
- The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine - Article
Podurgiel SJ , Yohn SE , Dortche K , María de las Mercedes Correa Sanz, Salamone JD .
BEHAVIOURAL BRAIN RESEARCH ; 298 pp. --. (2016). ISSN: 0166-4328
- Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat - Article
Samantha E. Yohn, Laura López Cruz, Peter H. Hutson, María de las Mercedes Correa Sanz, John D. Salamone.
PSYCHOPHARMACOLOGY ; 6 pp. 949-960. (2016). ISSN: 0033-3158
- The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences - Article
JD. Salamone, María de las Mercedes Correa Sanz, S. Yohn, Laura López Cruz, Noemí San Miguel Segura, L. Alatorre.
BEHAVIOURAL PROCESSES ; 127 pp. 3-17. (2016). ISSN: 0376-6357
- Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism - Article
Podurgiel SJ , Spencer T , Kovner R , Baqi Y , Müller CE , María de las Mercedes Correa Sanz, Salamone JD .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 140 pp. 62-67. (2016). ISSN: 0091-3057
- Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice - Article
María de las Mercedes Correa Sanz, Marta Pardo Andrés, Pilar Bayarri Iturralde, Laura López Cruz, Noemí San Miguel Segura, O Valverde, C Ledent, J.D. Salamone.
PSYCHOPHARMACOLOGY ; 3 pp. 393-404. (2016). ISSN: 0033-3158
- Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology - Article
SE. Yohn, EE. Errante, A. Rosenbloom-Snow, M. Somerville, M. Rowland, K. Tokarski, N. Zafar, María de las Mercedes Correa Sanz, JD. Salamone.
NEUROPHARMACOLOGY; 109 pp. 270-280. (2016). ISSN: 0028-3908
- Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040 - Article
S.E. Yohn, A. Gogoj, A. Haque, Laura López Cruz, P. Huxley, P. Basquín, María de las Mercedes Correa Sanz, JD. Salamone.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 148 pp. 84-91. (2016). ISSN: 0091-3057
- Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior - Article
SE. Yohn, SL. Collins, HM. Contreras-Mora, EL Errante, MA. Rowland, María de las Mercedes Correa Sanz, HD. Salamone.
NEUROPSYCHOPHARMACOLOGY; 3 pp. 686-694. (2016). ISSN: 0893-133X
- Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization - Article
SE Yohn, Y Arif, A Haley, G Tripodi, Y Baqi, CE Muller, Noemí San Miguel Segura, María de las Mercedes Correa Sanz, JD Salamone.
PSYCHOPHARMACOLOGY ; 19-20 pp. 3575-3586. (2016). ISSN: 0033-3158
- Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology - Revisió
J D. Salamone, SE. Yohn, Laura López Cruz, Noemí San Miguel Segura, María de las Mercedes Correa Sanz.
BRAIN ; 139 pp. 1325-1347. (2016). ISSN: 0006-8950
- The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A(2A) antagonist MSX-3 and the catecholamine uptake - Article
S.E. Yohn, C. Thompson, P.A. Randall, C.A. Lee, C.E. Müller, Y. Baqi, María de las Mercedes Correa Sanz, J.D. Salamone.
PSYCHOPHARMACOLOGY ; 7 pp. 1313-1323. (2015). ISSN: 0033-3158
- Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D-1, D-2, and D-3 receptor antagonists - Article
Marta Pardo Andrés, Laura López Cruz, Noemí San Miguel Segura, J.D. Salamone, María de las Mercedes Correa Sanz.
PSYCHOPHARMACOLOGY ; 13 pp. 2377-2391. (2015). ISSN: 0033-3158
- Bupropion Increases Selection of High Effort Activity in Rats Tested on a Progressive Ratio/Chow Feeding Choice Procedure: Implications for Treatment of Effort-Related Motivational Symptoms - Article
P.A. Randall, C.A. Lee, S.J. Podurgiel, E.E. Hart, M. Jones, M. Rowland, Laura López Cruz, María de las Mercedes Correa Sanz, J.D. Salamone.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; 2 pp. 1-11. (2015). ISSN: 1461-1457
- The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists - Article
S.E. Yohn, J.L. Santerre, E.J. Nunes, R. Kozak, S.J. Podurgiel, María de las Mercedes Correa Sanz, J.D. Salamone.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR; 135 pp. 217-226. (2015). ISSN: 0091-3057
- Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism - Article
S.J. Podurgiel, M. Milligan, S.E. Yohn, L. Purcell, H.M.M. Contreras, María de las Mercedes Correa Sanz, J.D. Salamone.
NEUROPSYCHOPHARMACOLOGY; 9 pp. 2240-2247. (2015). ISSN: 0893-133X
- Neurobiological basis of motivational deficits in psychopathology - Revisió
J.D. Salamone, I. Koychev, María de las Mercedes Correa Sanz, P. McGuire.
EUROPEAN NEUROPSYCHOPHARMACOLOGY; 8 pp. 1225-1238. (2015). ISSN: 0924-977X
Capítols de llibres
(Veure detalls)
- Parsing the Role of Mesolimbic Dopamine in Specific Aspects of Motivation: Behavioral Activation, Invigoration, and Effort-Based Decision Making
John D. Salamone, María de las Mercedes Correa Sanz.
Advances in Motivation Science. Academic Press, Londres (Reino Unido). (2018). ISBN: 9780128141717
- Motor function and motivation
John D. Salamone, María de las Mercedes Correa Sanz.
Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, Amsterdam (Paises Bajos). (2017). ISBN: 9780128093245
- Neurobiology of Effort and the Role of Mesolimbic Dopamine
John D. Salamone, María de las Mercedes Correa Sanz.
Recent Developments in Neuroscience Research on Human Motivation. Emerald, Bingley (Reino Unido). (2017). ISBN: 9781786354747
- Mesolimbic Dopamine and the Regulation of Motivated Behavior
J.D Salamone, Marta Pardo Andrés, S.E Yohn, Laura López Cruz, Noemí San Miguel Segura, María de las Mercedes Correa Sanz.
Behavioral Neuroscience of Motivation. Springer, (756) (Suiza). (2016). ISBN: 9783319269337
- Section V: Chapter 38: Physiological and Behavioral Assessment of Tremor in Rodents
J.D Salamone, S.J Podurgiel, L.E Collins-Praino, María de las Mercedes Correa Sanz.
Movement Disorders: Genetics and Models. Elsevier, Amsterdam (Paises Bajos). (2015). ISBN: 9780124051959
- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism.
J.D Salamone, S Podurgiel, L.L Long, E.J Nunes, María de las Mercedes Correa Sanz.
The Adenosinergic System: A non-dopaminergic target in Parkinson's Disease. Springer, (756) (Suiza). (2015). ISBN: 9783319202723
Treballs presentats en congressos publicats
(Veure detalls)
- Anergia and Effort-Related Aspects of Motivational Dysfunction in Animal Models of Depressive Symptoms: The Role of Mesolimbic Dopamine and Related Circuitry
John Salamone, María de las Mercedes Correa Sanz, Samantha Yohn, Renee Rotolo, Jeu-Hau Yan, Rose Presby.
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP). New York (Estados Unidos de América)
2018. ISSN: 0006-3223
Tesis dirigides
(Veure detalls)- Involvement of adenosinergic and dopaminergic systems in the regulation of alcohol or sucrose intake: studies in rodent models of self-administration
Autoria: San Miguel Segura, Noemí. Institució: Universitat Jaume I. Data lectura: 18/07/17Direcció: Correa Sanz, María de las Mercedes
- The effects of adenosine antagonists on distinct aspects of motivated behavior: interaction with ethanol and dopamine depletion
Autoria: López Cruz, Laura. Institució: Universitat Jaume I. Data lectura: 18/05/16Direcció: Correa Sanz, María de las Mercedes; Salamone, John
Altres dades
(Veure detalls)- Col·laboració amb el Laboratori de Neurociència Conductual del Departament de Psicologia de la Universitat de Connecticut, Estats Units.