GONZÁLEZ GUZMÁN, MIGUEL
My research career has focused on molecular mechanism controlling plant stress responses leading to plant stress tolerance. Plant stress responses are controlled by the fine tuning interaction of plant hormones as abscisic acid (ABA) or jasmonic acid derivates (JAs). Indeed, ABA steers a multitude of plant adaptive responses that enhances plant survival and productivity under stress conditions and is a pivotal target for plant biotechnology.
During my PhD, I identified new mutant alleles of ABA biosynthesis ABA1, ABA2 and AAO3 genes as key players of plant abiotic stress response. We showed that ABA functions not only in plant stress responses but also in plant growth of non-stressed plants.
During my postdoctoral in Gent, I was focused on JA-dependent reprogramming of plant secondary metabolism in plant biotic stress conditions. We identified an ERAD -type RING membrane-anchor E3 ubiquitin ligase controlling the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), showing that JAs phytohormone recruits the ERAD quality control system to manage the production of plant defence metabolite synthesis.
As postdoctoral of the ABA signalling group of Dr. Pedro Rodriguez, I have been involved in the characterization of core ABA signalling elements as well in the identification of new components of the ABA signalling pathway using Arabidopsis and tomato plants. As a result, I have established the predominant role in planta of PYR/PYL/RCAR ABA receptors in ABA signalling against others ABA receptors identified. Moreover, I have found new ABA signalling players including two regulatory proteins of the ABA PYR/PYL/RCAR receptors involved in ABA signalling membrane-delimited events.
In collaboration with several Europeans groups, I have found hormonal crosstalk between ABA signalling and others signalling pathways. Of relevant interest is the crosstalk between biotic and abiotic plant stress responses I found since many times crops have to survive to a combination of both stresses. Understanding the molecular mechanism of this hormonal crosstalk has a high biotechnological potential. To increase my knowledge of stress combination I stayed from 2015 to 2018 at Plant-Insect Interaction group headed by Prof. Pedro Castañera and Dr. Felix Ortego where I obtained a Young Investigator (JIN) project from the Spanish Government to develop a research line to understand hormonal signalling mechanisms steering plant stress tolerance under stress combination.
In 2017, I obtained a Ramon y Cajal research contract which allow me to join the Ecofisiología y Biotecnología headed by the professor Aurelio Gomez Cadenas where I am continuing my research line “Hormonal signalling mechanisms steering plant stress tolerance under stress combination”.
Horari de tutories de Miguel González Guzmán
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El professor/a té tutories virtuals en el primer semestre
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El professor/a té tutories virtuals en el segon semestre
Assignatures amb docència
|MD1704 - Biología||Grado en Medicina (Plan de 2017)|
|MD1711 - Genética Humana||Grado en Medicina (Plan de 2017)|
Publicacions periòdiques amb comitè de selecció
- Plant-Mediated Effects of Water Deficit on the Performance of Tetranychus evansi on Tomato Drought-Adapted Accessions
- Estudio de la herencia y mapeo de la resistencia de Ceratitis capitata (Wiedemann, 1824) (Diptera, Tephritidae) al insecticida λ-cihalotrina
- Structure of Ligand-Bound Intermediates of Crop ABA Receptors Highlights PP2C as Necessary ABA Co-receptor
- Depletion of abscisic acid levels in roots of flooded Carrizo citrange (Poncirus trifoliata L. Raf. × Citrus sinensis L. Osb.) plants is a stress-specific response associated to the differential expression of PYR/PYL/RCAR receptors
- The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
- FYVE1/FREE1 Interacts with the PYL4 ABA Receptor and Mediates Its Delivery to the Vacuolar Degradation Pathway
- Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling
- A Direct Link between Abscisic Acid Sensing and the Chromatin-Remodeling ATPase BRAHMA via Core ABA Signaling Pathway Components
- Inactivation of PYR/PYL/RCAR ABA receptors by tyrosine nitration may enable rapid inhibition of ABA signaling by nitric oxide in plants
- A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions
- The IBO germination quantitative trait locus encodes a phosphatase 2C-related variant with a nonsynonymous amino acid change that interferes with abscisic acid signaling
- The single-subunit RING-type E3 ubiquitin ligase RSL1 targets PYL4 and PYR1 ABA receptors in plasma membrane to modulate abscisic acid signaling
- C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis
- Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance
- A forward genetic approach in Arabidopsis thaliana identifies a RING-type ubiquitin ligase as a novel determinant of seed longevity
- The protein quality control system manages plant defence compound synthesis
- ABI1 and PP2CA Phosphatases Are Negative Regulators of Snf1-Related Protein Kinase1 Signaling in Arabidopsis
- The PYL4 A194T Mutant Uncovers a Key Role of PYR1-LIKE4/PROTEIN PHOSPHATASE 2CA Interaction for Abscisic Acid Signaling and Plant Drought Resistance
- PYR/RCAR Receptors Contribute to Ozone-, Reduced Air Humidity-, Darkness-, and CO2-Induced Stomatal Regulation
- PYRABACTIN RESISTANCE1-LIKE8 Plays an Important Role for the Regulation of Abscisic Acid Signaling in Root
- Arabidopsis PYR/PYL/RCAR Receptors Play a Major Role in Quantitative Regulation of Stomatal Aperture and Transcriptional Response to Abscisic Acid
- Selective Inhibition of Clade A Phosphatases Type 2C by PYR/PYL/RCAR Abscisic Acid Receptors
- Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs
- A thermodynamic switch modulates abscisic acid receptor sensitivity
- Crystallization and preliminary crystallographic analysis of a C2 protein from Arabidopsis thaliana
- News on ABA transport, protein degradation, and ABFs/WRKYs in ABA signaling
- An Integrated PCR Colony Hybridization Approach to Screen cDNA Libraries for Full-Length Coding Sequences
- Modulation of Abscisic Acid Signaling in Vivo by an Engineered Receptor-Insensitive Protein Phosphatase Type 2C Allele
- Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco
- Determination of saponins in Maesa lanceolata by LC-UV: Development and validation
- An Arabidopsis Mutant Impaired in Coenzyme A Biosynthesis Is Sugar Dependent for Seedling Establishment
- A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights the involvement of ABA in vegetative development
- Two New Alleles of the abscisic aldehyde oxidase 3 Gene Reveal Its Role in Abscisic Acid Biosynthesis in Seeds
- Gain-pf-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling
- The Short-Chain Alcohol Dehydrogenase ABA2 Catalyzes the Conversion of Xanthoxin to Abscisic Aldehyde
- The short-chain alcohol dehydrogenase ABA2 catalyzes hte conversion of xanthoxin into abscisic aldehyde
- A combination of the F-box motif and kelch repeats defines a large Arabidopsis family of F-box proteins
- Genética molecular de la biosíntesis del ácido abscísico. Clonación y caracterización del gen ABA2
Ponències a congressos
- Estudio de la herencia y mapeo de la resistencia de Ceratitis capitata (Wiedemann, 1824) (Diptera, Tephritidae) al insecticida lambda-cihalotrina
- Plant-mediated effects of water deficit on the performance of tetranyhus evansi on tomato drought-adapted accesions
- The multigene family of PYR/PYL/RCAR abscisic acid receptors plays a pivotal role for ABA signaling
- Nitric oxide negatively regulates ABA sensitivity by PYR/PYL/RCAR nitration
- A mutational analysis of the ABA1 gene in Arabidopsis thaliana
- The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin into abscisic aldehyde
Referee de publicacions periòdiques
- Miguel González Guzmán. 2018 FRONTIERS IN PLANT SCIENCE.
- Miguel González Guzmán. 2017 JOURNAL OF PLANT PHYSIOLOGY.
- Miguel González Guzmán. 2017 PLANT CELL.